A Meta-analysis on the correlation between the polymorphism of angiotensin converting enzyme gene and hypertrophic cardiomyopathy

Ling CHEN, Yu WANG, Ge LI

Abstract


Objective To systematically investigate the correlation between the polymorphism of angiotensin converting enzyme (ACE) gene I/D and hypertrophic cardiomyopathy. Methods The databases, such as PubMed, Embase, OVID, Web of Science, Cochrane library, CNKI, WanFang Data and VIP, were searched to collect the studies on the correlation between ACE I/D polymorphism and hypertrophic cardiomyopathy susceptibility. Studies that met the inclusion criteria were Meta-analyzed using Stata 11.0 software. Results Fifteen articles were collected including 1114 cases and 1648 controls. The Meta-analysis indicated that there was significant correlation between the 4 models of ACE I/D polymorphism and hypertrophic cardiomyopathy susceptibility [D vs I: OR=1.49, 95%CI (1.20, 1.84); DD vs (ID+II): OR=1.56, 95%CI (1.17, 2.08); (DD+ID ) vs II: OR=1.76, 95%CI (1.30, 2.38); DD vs II: OR=2.20, 95%CI (1.44, 3.37)]. In subgroup analysis, the significant difference existed in Asian population, but no significance was found in European population (P

Keywords


peptidyl-dipeptidase A; gene polymorphism; cardiomyopathy, hypertrophic; Meta-Analysis

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