Application of mobile blood purification system in the treatment of acute renal failure dog model in the field environment

Zhi-min ZHANG, Wei ZHOU, Ping LI, Wu-xing ZHANG, Hai-bin LI, Tao YU, Yang LI, Bao-yan WU, Bing-yi SHI

Abstract


Objective To evaluate the stability, safety and efficacy of mobile blood purification system in the treatment of acute renal failure dog model in the field environment. Methods The acute renal failure model was established in 4 dogs by bilateral nephrectomy, which was thereafter treated with the mobile blood purification system. The evaluation of functional index of the mobile blood purification system was performed after a short-time (2 hours) and conventional (4 hours) dialysis treatment. Results The mobile blood purification system ran stably in the field environment at a blood flow of 150-180ml/min, a dialysate velocity of 2000ml/h, a replacement fluid velocity of 2000ml/h, and ultrafiltration rate of 100-200ml/h. All the functions of alarming system worked well, including static upper limit alarm of ultrafiltration pressure (>100 mmHg), upper limit alarm of ambulatory arterial pressure (>400mmHg), upper limit alarm of ambulatory venous pressure (>400mmHg), bubble alarm of vascular access, bubble alarm during the infusion of solutions, pressure alarm at the substitution pump segment and blood leaking alarm. The vital signs of the 4 dogs with acute renal failure kept stable during the treatment. After the treatment, a remarkable decrease was seen in the levels of serum urea nitrogen, creatinine and serum potassium (P0.05). Conclusions The mobile blood purification system runs normally even in a field environment. It is a flexible and portable device with a great performance in safety and stability in the treatment of acute renal failure.

DOI: 10.11855/j.issn.0577-7402.2013.12.15

Keywords


blood purification system; acute renal failure; animal experimentation; dialysis

Full Text: PDF

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.